:root{--navy:#062f67;--navy2:#0b3d76;--blue:#047fcf;--cyan:#08a9e2;--ink:#122e56;--muted:#5b6f85;--line:#e4eaf0;--soft:#f6f9fc}
*{box-sizing:border-box}html{scroll-behavior:smooth}body{margin:0;font-family:Inter,Arial,sans-serif;color:var(--ink);line-height:1.55;background:#fff}.shell{width:min(1380px,calc(100% - 72px));margin:auto}
.site-header{height:88px;position:sticky;top:0;z-index:50;background:rgba(255,255,255,.97);backdrop-filter:blur(12px);border-bottom:1px solid #e8edf2}.nav-shell{height:100%;display:flex;align-items:center;justify-content:space-between;gap:30px}.site-logo{height:82px;display:flex;align-items:center;overflow:hidden}.site-logo img{width:220px;height:82px;object-fit:contain;object-position:left center}.nav-links{display:flex;align-items:center;gap:22px}.nav-links a{text-decoration:none;color:#17365d;font-size:12px;font-weight:600;white-space:nowrap}.nav-links a.active{color:#0784c9}.portal-btn{background:#062f67;color:#fff!important;border-radius:5px;padding:12px 14px}.menu-toggle{display:none;border:0;background:none;font-size:28px;color:var(--navy)}
.hero{height:450px;position:relative;overflow:hidden;background:linear-gradient(90deg,#fff 0,#fff 41%,#eef7fc 100%)}.hero-art{position:absolute;left:40%;right:0;inset-block:0;background:linear-gradient(90deg,#fff 0,rgba(255,255,255,.62) 16%,rgba(255,255,255,0) 46%),url("assets/hero-ccta.jpg") center/cover no-repeat}.hero-inner{height:100%;display:flex;align-items:center;position:relative}.hero-copy{width:610px}.eyebrow{display:block;font-size:10px;font-weight:800;letter-spacing:.17em;color:#078acb}.hero h1{font-size:43px;line-height:1.08;letter-spacing:-.035em;margin:13px 0}.hero h1 span{color:#0780cf}.rule{width:40px;height:3px;background:#078fd2;margin:18px 0}.hero p{font-size:16px;color:#3b516a;max-width:570px}.actions{display:flex;gap:14px;margin-top:26px}.button{display:inline-flex;align-items:center;justify-content:center;text-decoration:none;font-size:12px;font-weight:700;border-radius:5px;padding:13px 20px}.button.primary{background:#062f67;color:#fff}.button.secondary{background:#fff;color:#0e4278;border:1px solid #16477a}
.metrics{background:linear-gradient(90deg,#062f67,#073c77);color:#fff}.metrics-grid{height:96px;display:grid;grid-template-columns:repeat(5,1fr)}.metrics-grid>div{display:flex;flex-direction:column;align-items:center;justify-content:center;text-align:center;border-right:1px solid rgba(255,255,255,.15)}.metrics-grid>div:last-child{border:0}.metrics strong{font-size:22px}.metrics span{font-size:10px;opacity:.88}
.section{padding:76px 0}.section.soft{background:var(--soft)}.section-intro{display:grid;grid-template-columns:1.05fr 1fr;gap:80px;align-items:end;margin-bottom:34px}.section h2{font-size:32px;line-height:1.2;letter-spacing:-.02em}.section-intro p{color:var(--muted)}.feature-grid,.home-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}.feature,.nav-card{border:1px solid var(--line);border-radius:9px;padding:25px;background:#fff;box-shadow:0 5px 18px rgba(28,50,78,.035)}.round-icon{width:55px;height:55px;border-radius:50%;background:#eaf6fc;display:grid;place-items:center;color:#0b3e79;font-size:27px}.feature h3{margin:16px 0 7px;font-size:16px}.feature p,.nav-card p{font-size:12px;color:var(--muted)}.home-split{display:grid;grid-template-columns:1.2fr .8fr;gap:70px;align-items:center}.text-link{color:#0786c9;text-decoration:none;font-size:12px;font-weight:700}.callout-card{background:#fff;border:1px solid var(--line);border-radius:10px;padding:26px;box-shadow:0 10px 34px rgba(23,50,83,.07)}.callout-card h3{margin-top:0}.callout-card p{font-size:12px;color:var(--muted)}.nav-card{text-decoration:none;color:var(--ink);transition:.2s}.nav-card:hover{transform:translateY(-2px);box-shadow:0 12px 28px rgba(28,50,78,.08)}.nav-card>span{font-size:9px;letter-spacing:.16em;color:#078aca;font-weight:800}.nav-card h3{font-size:17px}.nav-card b{font-size:11px;color:#0786c9}
.page-hero{padding:65px 0;background:linear-gradient(120deg,#f8fbfe,#edf6fb);border-bottom:1px solid var(--line)}.page-hero h1{font-size:42px;letter-spacing:-.03em;margin:8px 0}.page-hero p{max-width:720px;color:var(--muted)}.patient-grid{display:grid;grid-template-columns:1fr 340px;gap:70px}.patient-main h2{font-size:24px;margin-top:36px}.patient-main h2:first-child{margin-top:0}.patient-main p,.check-list{color:#4f647a;font-size:14px}.check-list{padding-left:20px}.check-list li{margin:9px 0}.sticky{position:sticky;top:120px}.mini-contact{margin-top:18px;padding:20px;background:#f7fafd;border-radius:8px}.mini-contact b,.mini-contact span,.mini-contact a{display:block;font-size:11px;margin:4px 0}.mini-contact a{color:#0786c9}
.subhead{margin:8px 0 24px;font-size:28px}.steering-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:17px}.steering-grid article{padding:24px;border-left:4px solid #078fd2;background:#f9fbfd}.steering-grid h3{font-size:15px;margin-top:0}.steering-grid p{font-size:11px;color:var(--muted)}.divider{height:1px;background:var(--line);margin:58px 0}.centre-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:12px}.centre-grid article{border:1px solid var(--line);border-radius:7px;padding:17px}.centre-grid b{display:block;font-size:12px}.centre-grid span{display:block;color:#0787c8;font-size:10px;margin-top:4px}.people-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:0 18px}.people-grid span{padding:9px 0;border-bottom:1px solid #edf1f4;font-size:11px}.note{font-size:10px;color:#73879b;font-style:italic;margin-top:18px}
.study-grid{display:grid;grid-template-columns:1.4fr 1fr;gap:18px}.study-card{border:1px solid var(--line);border-radius:9px;padding:28px}.study-card.featured{grid-row:span 2;background:linear-gradient(145deg,#f7fbfe,#fff)}.study-card>span{font-size:9px;color:#078aca;font-weight:800;letter-spacing:.14em}.study-card h2{font-size:24px}.study-card p{font-size:13px;color:var(--muted)}.study-stats{display:flex;flex-wrap:wrap;gap:8px;margin:20px 0}.study-stats b,.status{background:#eaf6fc;color:#0a568a;padding:7px 10px;border-radius:999px;font-size:10px}.status{display:inline-block;margin-top:15px}
.publication-card{border:1px solid var(--line);border-radius:10px;padding:32px}.publication-card h2{font-size:28px;max-width:950px}.pub-facts{display:grid;grid-template-columns:repeat(4,1fr);gap:12px;margin:28px 0}.pub-facts div{padding:18px;background:#f6fafd;border-radius:7px}.pub-facts b{display:block;font-size:23px}.pub-facts span{font-size:10px;color:var(--muted)}.muted{color:var(--muted)}
.resource-grid{display:grid;grid-template-columns:1fr 1fr;gap:15px}.resource-card{display:grid;grid-template-columns:52px 1fr auto;gap:16px;align-items:center;border:1px solid var(--line);border-radius:8px;padding:20px;text-decoration:none;color:var(--ink)}.resource-card i{width:48px;height:48px;background:#eaf6fc;color:#0789ca;border-radius:6px;display:grid;place-items:center;font-style:normal;font-size:9px;font-weight:800}.resource-card h3{font-size:14px;margin:0 0 4px}.resource-card p{font-size:11px;color:var(--muted);margin:0}.resource-card>b{font-size:10px;color:#0787c8}.resource-card.disabled{opacity:.7}
.contact-page{display:grid;grid-template-columns:1fr 420px;gap:80px}.contact-detail{border-top:1px solid var(--line);padding:14px 0}.contact-detail span{display:block;font-size:9px;color:#718397;text-transform:uppercase;letter-spacing:.12em}.contact-detail a,.contact-detail b{font-size:14px;color:var(--ink);text-decoration:none}
footer{background:#062f67;color:#fff;padding:34px 0 16px}.footer-grid{display:grid;grid-template-columns:1.5fr 1fr .7fr;gap:35px;align-items:center}.footer-brand{display:flex;align-items:center;gap:14px}.footer-brand img{width:92px;height:65px;object-fit:contain;background:#fff;border-radius:4px}.footer-grid b,.footer-grid span,.footer-grid a{display:block;font-size:10px}.footer-grid a{color:#62d2f4;text-decoration:none}.copyright{border-top:1px solid rgba(255,255,255,.16);margin-top:20px;padding-top:14px;font-size:9px;color:#aec4d7}
@media(max-width:1120px){.nav-links{display:none;position:absolute;top:88px;left:0;right:0;background:#fff;flex-direction:column;align-items:stretch;padding:20px 30px;border-bottom:1px solid var(--line)}.nav-links.open{display:flex}.menu-toggle{display:block}.hero-art{left:25%;opacity:.6}.metrics-grid{height:auto;grid-template-columns:repeat(2,1fr)}.metrics-grid>div{padding:18px}.feature-grid,.home-grid,.section-intro,.home-split,.patient-grid,.contact-page,.study-grid{grid-template-columns:1fr}.steering-grid,.centre-grid{grid-template-columns:1fr 1fr}.people-grid{grid-template-columns:repeat(3,1fr)}.footer-grid{grid-template-columns:1fr 1fr}}
@media(max-width:700px){.shell{width:min(100% - 28px,1380px)}.site-logo img{width:170px}.hero{height:520px}.hero-art{left:0;opacity:.25}.hero-copy{width:auto}.hero h1{font-size:35px}.actions{flex-direction:column;align-items:flex-start}.metrics-grid{grid-template-columns:1fr}.feature-grid,.home-grid,.steering-grid,.centre-grid,.people-grid,.resource-grid,.pub-facts{grid-template-columns:1fr}.page-hero h1{font-size:34px}.footer-grid{grid-template-columns:1fr}.footer-brand img{width:80px}}

.research-team-grid{display:grid;grid-template-columns:repeat(5,1fr);gap:10px}
.research-team-grid span{padding:15px 12px;border:1px solid var(--line);border-radius:7px;background:#fff;font-size:11px;font-weight:600}
.logo-centre-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px}
.logo-centre{display:grid;grid-template-columns:155px 1fr;gap:20px;align-items:center;min-height:135px;border:1px solid var(--line);border-radius:9px;padding:18px;background:#fff}
.centre-logo{height:92px;display:flex;align-items:center;justify-content:center;overflow:hidden;background:#fff;border-radius:5px}
.centre-logo img{max-width:100%;max-height:88px;object-fit:contain}
.logo-centre b{display:block;font-size:13px;line-height:1.4}.logo-centre span{display:block;font-size:10px;color:var(--muted);margin-top:6px}
.wordmark{text-align:center;color:#0874bd;font-weight:800;font-size:17px;line-height:1.1;letter-spacing:.02em}
.wordmark small{font-size:7px;letter-spacing:.12em;color:#4c6b86}.konstantopouleio{font-size:12px;color:#355d7b}
.logo-note{font-size:9px;color:#718397;margin-top:14px;font-style:italic}
@media(max-width:950px){.research-team-grid{grid-template-columns:repeat(2,1fr)}.logo-centre-grid{grid-template-columns:1fr}}
@media(max-width:600px){.research-team-grid{grid-template-columns:1fr}.logo-centre{grid-template-columns:110px 1fr}}

/* v7 bilingual header */
.site-header{height:auto!important;background:rgba(255,255,255,.98)!important}
.brand-row{min-height:104px;display:grid;grid-template-columns:250px 1fr auto;align-items:center;gap:28px}
.site-logo{height:96px!important;display:flex;align-items:center!important}
.site-logo img{width:230px!important;height:94px!important;object-fit:contain}
.institutional-strip{display:flex;align-items:center;gap:34px}
.institution{display:flex;align-items:center;gap:10px;min-width:230px}
.institution img{width:54px;height:54px;object-fit:contain}
.institution span{font-size:9px;line-height:1.35;color:#284766;font-weight:700}
.lang-switch{display:flex;gap:6px;justify-content:flex-end}
.lang-switch a{min-width:36px;text-align:center;border:1px solid #cdd9e5;border-radius:4px;padding:7px 8px;text-decoration:none;color:#0b3d75;font-size:11px;font-weight:800}
.lang-switch .active-lang{background:#062f67;color:#fff;border-color:#062f67}
.nav-bar{border-top:1px solid #edf1f5;border-bottom:1px solid #e8edf2;background:#fff}
.nav-shell{height:54px!important}
.nav-links{width:100%;justify-content:center}
.site-header + main .hero{margin-top:0}
@media(max-width:1120px){
  .brand-row{grid-template-columns:210px 1fr auto;gap:15px}.site-logo img{width:200px!important}
  .institutional-strip{gap:16px}.institution{min-width:auto}.institution span{display:none}.institution img{width:45px;height:45px}
  .nav-links{top:158px!important}
}
@media(max-width:700px){
  .brand-row{grid-template-columns:1fr auto}.institutional-strip{grid-column:1/-1;justify-content:flex-start;padding-bottom:10px}.institution span{display:block;font-size:8px}
  .site-logo img{width:180px!important;height:80px!important}.nav-links{top:196px!important}
}

/* v8 investigator authentication prototype */
.auth-shell{max-width:520px;margin:0 auto}
.auth-card{border:1px solid var(--line);background:#fff;border-radius:12px;padding:30px;box-shadow:0 12px 36px rgba(20,48,82,.08)}
.auth-card h2{margin-top:0}.auth-card label{display:block;font-size:11px;font-weight:700;margin:14px 0 6px}
.auth-card input,.auth-card select{width:100%;height:44px;border:1px solid #d4dee8;border-radius:6px;padding:0 12px;font:inherit}
.auth-card .button{width:100%;margin-top:18px;border:0;cursor:pointer}
.auth-note{margin-top:14px;font-size:10px;color:#718397;background:#f7fafc;border-left:3px solid #0a8ecf;padding:10px 12px}
.auth-links{display:flex;justify-content:space-between;gap:12px;margin-top:14px;font-size:11px}
.auth-links a{color:#0786c9;text-decoration:none}
.alert{display:none;margin:12px 0 0;padding:10px 12px;border-radius:6px;font-size:11px}
.alert.error{display:block;background:#fff2f2;color:#8e1f1f;border:1px solid #f0caca}
.alert.success{display:block;background:#effaf3;color:#1f6d3c;border:1px solid #c9ead5}
.portal-head{display:flex;align-items:flex-start;justify-content:space-between;gap:20px;margin-bottom:26px}
.user-chip{padding:9px 12px;border:1px solid var(--line);border-radius:999px;font-size:10px;background:#fff}
.resource-card.protected{position:relative}.protected-badge{font-size:9px!important;background:#062f67;color:#fff!important;border-radius:999px;padding:5px 8px}
.portal-warning{background:#fff8e9;border:1px solid #f1ddb2;border-radius:8px;padding:12px 14px;color:#6a5729;font-size:10px;margin:0 0 24px}
.logout-btn{background:none;border:1px solid #cdd9e5;color:#0b3d75;border-radius:5px;padding:8px 11px;font-size:10px;font-weight:700;cursor:pointer}
@media(max-width:700px){.portal-head{flex-direction:column}.auth-card{padding:22px}}


/* v9 Supabase authentication */
.field-help{font-size:9px;color:#718397;margin-top:5px}
.auth-card button:disabled{opacity:.65;cursor:wait}
.approval-box{background:#fff8e9;border:1px solid #f1ddb2;border-radius:9px;padding:20px 22px;margin-bottom:24px}
.approval-box.neutral{background:#f5f9fc;border-color:#dbe7f0}
.approval-box h3{margin:0 0 7px;font-size:17px}.approval-box p{margin:0;color:#5b6f85;font-size:12px}
.secure-banner{background:#eff8f4;border:1px solid #cce8d8;border-radius:8px;padding:12px 14px;color:#2a5f42;font-size:10px;margin:0 0 24px}
.resource-card.loading{opacity:.65;pointer-events:none}
.patient-info-card{margin-top:16px}